حَتَّىٰٓ إِذَا فَتَحْنَا عَلَيْهِم بَابًا ذَا عَذَابٍ شَدِيدٍ إِذَا هُمْ فِيهِ مُبْلِسُونَ Qur’an Al-Muminun (23:77)Hatta itha fatahna AAalayhim baban tha AAathabin shadeedin itha hum feehi mublisoona
Or: "they will despair of all hope".
Cf. vi. 44. If the little trials in the present life will not open their eyes, will great trials do so? Unfortunately they only cause in the wicked a feeling of despair. In the final Punishment after the Judgment, it will be too late for them to repent, and despair will be their only lot.